Latin America remains on the margins of recent academic debates on how populism influences the foreign policy of states. In order to advance the discussion on the subject, we propose the hybridization of the Latin American experience with international references on the subject. The result of this process is a road map for studying populist foreign policy from Latin America, comprising four axes of analysis: (a) the reproduction of the us/them dichotomy in global politics, associated with different ideologies, (b) the use of critical discourses towards the world scenario, (c) the centralization of foreign policy decision-making around the leader, and (d) the conditioning factors imposed by the position of Latin American countries in the world system as a fundamental restriction to the aspirations for change of populist foreign policies.